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In neuroscience, Dale's principle (or Dale's law) is a rule attributed to the English neuroscientist Henry Hallett Dale. The principle basically states that a neuron performs the same chemical action at all of its synaptic connections to other cells, regardless of the identity of the target cell. However, there has been disagreement about the precise wording. Because of an ambiguity in the original statement, there are actually two versions of the principle, one that has been shown definitively to be false, and another that remains a valuable rule of thumb. The term "Dale's Principle" was first used by Sir John Eccles in 1954, in a passage reading, "In conformity with Dale's principle (1934, 1952) that the same chemical transmitter is released from all the synaptic terminals of a neurone…" Some modern writers have understood the principle to state that ''neurons release one and only one transmitter at all of their synapses''. Others, including Eccles himself in later publications, have taken it to mean that ''neurons release the same set of transmitters at all of their synapses''. Dale himself never stated his "principle" in an explicit form. The source that Eccles referred to was a lecture published by Dale in 1934, called ''Pharmacology and nerve endings'', describing some of the early research into the physiology of neurotransmission.〔 At that time, only two chemical transmitters were known, acetylcholine and noradrenaline (then thought to be adrenaline).〔The name "adrenaline" is used because this is a historical account. This chemical is now officially called epinephrine〕 In the peripheral nervous system, cholinergic and adrenergic transmission were known to arise from different groups of nerve fibers. Dale was interested in the possibility that a neuron releasing one of these chemicals in the periphery might also release the same chemical at central synapses. He wrote:
And near the end of the paper:
With only two transmitter chemicals known to exist at the time, the possibility of a neuron releasing more than one transmitter at a single synapse did not enter anybody's mind, and so no care was taken to frame hypotheses in a way that took this possibility into account. The resulting ambiguity in the initial statements led to some confusion in the literature about the precise meaning of the principle. Nicoll and Malenka, for example, understood it to state that a neuron always releases one and only one neurotransmitter at all of its synapses. In this form it is certainly false. Many neurons release more than one neurotransmitter, in what is called "cotransmission". Although there were earlier hints, the first formal proposal of this discovery did not come until 1976. Most neurons release several different chemical messengers. In a 1976 publication, however, Eccles reinterpreted the principle in a subtly different way:
The addition of "or substances" is critical. With this change, the principle allows for the possibility of neurons releasing more than one transmitter, and only asserts that the same set are released at all synapses. In this form, it continues to be an important rule of thumb, with only a few known exceptions., including David Sulzer and Stephen Rayport's finding that dopamine neurons also release glutamate as a neurotransmitter, but at separate release sites. In modern neuroscience, neurons are often classified by their neurotransmitter and most important cotransmitter, for example striatal GABA neurons utilize either opioid peptides or substance P as the primary cotransmitter. Neurons in a class without a subpopulation of inhibitory interneurons can release at least two neurotransmitters at the same time, the other being a cotransmitter, in order to provide the stabilizing negative feedback required for meaningful encoding. Examples include: * GABA–glycine co-release * Dopamine–glutamate co-release * Dopamine–GABA co-release 〔Tritsch NX, Ding JB, Sabatini BL. Dopaminergic neurons inhibit striatal output through non-canonical release of GABA. Nature. 2012 Oct 11;490(7419):262-6. doi: 10.1038/nature11466. Epub 2012 Oct 3. PubMed PMID 23034651; PubMed Central PMCID: PMC3944587〕 * Acetylcholine–glutamate co-release * Acetylcholine–vasoactive intestinal peptide co-release * Acetylcholine–calcitonin gene-related peptide co-release * Glutamate–dynorphin co-release (in Hippocampus) ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Dale's principle」の詳細全文を読む スポンサード リンク
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